Szczegóły: Materials Science and Engineering C 45 (2014 ) 15–20.
One of the major problems in orthopedic surgery is infection associated with implantation. The treatment is a very difficult and long-term process. A solution to this issue can be the use of implants which additionally constitute an antibiotic carrier preventing the development of an infection. Prototypes of biodegradable intramedullary nails made of three different composites with a poly(L-lactide) matrix were designed. The nails served as gentamicin sulfate (GS) carrier — an antibiotic commonly used in the treatment of osteomyelitis. The matrix was reinforced with carbon fibers (CF), alginate fibers (Alg) and magnesium alloy wires (Mg), as well as modified with bioactive particles of tricalcium phosphate (TCP) in various systems. In this way, novel, multi-phase and multifunctional degradable intramedullary nails were obtained. The tests demonstrated strong dependence between the type of the modifying phase introduced into the composite, and the rate of drug release. Introduction of gentamicin into the nail structure strengthened and prolonged antibacterial activity of the nails.
Szczegóły: Acta of Bioengineering and Biomechanics 16 (2014) 3, 3–12.
Szczegóły: Bio-Medical Materials and Engineering 24 (2014) 2, 1507–1515.
Szczegóły: Journal of Composite Materials 48 (2014) 7, 815–824.
In the present article, new polylactide/alginate fibers composites were investigated. Composite pre-pregs were made by solution casting method. The aim of the study was to define physico-mechanical properties of developed materials. The scope of the studies included: examining the static mechanical properties, properties of the surface and their changes during degradation. Moreover, intensity of the release of degradation products to the environment and a change of the mass of examined samples were analyzed. Obtained results were evaluated taking into account possibility to use prepared composited as materials for vascular implants.